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FLASH GENE
Symbol ACACB contributors: mct/npt/shn - updated : 07-06-2016
HGNC name acetyl-CoA carboxylase beta
HGNC id 85
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
52 - 9260 - 2458 - 2009 19618481
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousnerve   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • carboxyl transferase domain
  • a biotin carboxylase (BC) domain (Cho 2010)
  • N-terminal sequences of ACC2 are responsible for mitochondrial targeting of ACC2
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Acacb, Mus musculus
    ortholog to Acacb, Rattus norvegicus
    ortholog to acacb, Danio rerio
    Homologene
    FAMILY
  • biotin containing enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text colocalizing with CPT1
    basic FUNCTION
  • biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis
  • may involved in the regulation of fatty acid beta-oxidation and energy production
  • activity of ACACB plays an important role in the disorders related to energy metabolism
  • regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria
  • is dispensable for CD8+ T cell responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    long chain fatty acid synthesis (mitochondrial)
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • biotin
  • protein
  • allosterically regulating CPT1 activity
  • PRKAA1 might regulate NADPH homeostasis by inhibiting ACACA and ACACB
  • cell & other
    REGULATION
    induced by MgoD1-MyoG and MYF6 (for the muscle specific expression via E.box
    inhibited by nuclear respiratory factor-1 (NRF-1) via AMPK activation
    AMPK
    Phosphorylated by ACACB and phosphorylation of ACACB S212 is required for the maintenance of skeletal muscle lipid and glucose homeostasis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    Cardiac-specific deletion of ACACB prevents metabolic remodeling during pressure-overload hypertrophy
    Susceptibility to obesity and diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapeutic target for obesity and diabetes (Cho 2010)
    ANIMAL & CELL MODELS
  • Acc2-/- mutant mice have a normal life span, a higher fatty acid oxidation rate, and lower amounts of fat