basic FUNCTION
| involved in early stage of clathrin coated pits mediated endocytosis and formation of synaptic vesicles |
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has evolved to form structures that fit the dimensions of mitochondria |
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producing microtubule bundles |
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large multidomain GTPase dynamin that self-assembles around the necks of deeply invaginated coated pits at the plasma membrane and catalyzes vesicle scission |
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with DNM1L act redundantly in peroxisome biogenesis, which is under cell cycle control |
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mediates mitochondrial fission during interphasic growth and at cell division |
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involved in activity-dependent synaptic vesicle endocytosis and membrane recycling |
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has potentially a mechanochemical role during mitochondrial division |
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is a master regulator of membrane fission in endocytosis |
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likely affects amyloid generation through regulation of BACE1 subcellular localization and therefore its enzymatic activities |
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DNM1, DNM2, DNM3, decode action potential firing for synaptic vesicle recycling |
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implicated in vesicular protein transport processes relevant to synaptic and post-Golgi pathways, indicating a possible role in photoreceptor stability |
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role in podocyte foot process maintenance |
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GTPase protein that polymerise during their biological activity |
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exclusively brain-expressed GTPase localizing to the presynaptic terminal |
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causative role of DNM1 mutations in severe epileptic encephalopathies, presenting evidence for a predominant role of synaptic dysregulation in epileptic encephalopathies |
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DNM1 and DNM2 act as key mediators of sperm acrosome formation and function |
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is a protein involved in the synaptic vesicle cycle, which facilitates the exocytosis of neurotransmitters necessary for normal signaling and development in the central nervous system |
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role of dynamin in dense-core vesicle endocytosis and secretory capacity |
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protein essential for clathrin-mediated endocytosis and synaptic vesicle recycling |
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