basic FUNCTION
| fatty acid-binding protein 4, involved in lipid transport protein in adipocytes |
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with hormone-sensitive lipase (LIPE), form a physical complex that affects basal and hormone-stimulated adipocyte fatty acid efflux ((Smith 2008) |
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having a role as a fatty acid sensor affecting cellular metabolism via protein-protein interactions (Thompson 2009) |
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fatty acid carrier solubilizing and enabling diffusion of fatty acids throughout the aqueous cellular environment (Thompson 2009) |
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mechanistic linkage between FABP4 and impaired endothelial function in diabetes, which leads to an increased cardiovascular risk. |
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is an adipokine linking adipocytes to hepatic glucose production |
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FABP4/5 is potentially novel targets for the modulation of energy homeostasis |
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cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis |
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might promote human prostate cancer cell progression by binding with fatty acids |
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is functionally expressed in endometrial epithelium and is necessary for maintaining the cell function of epithelial cells of endometrium |
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mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy |
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adipose tissue-secreted adipokine that is involved in the regulation of energetic metabolism and inflammation |
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plays an important role in regulating heart function under pressure overload |
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FABP4 over-expression in cardiomyocytes can aggravate the development of cardiac hypertrophy through the activation of ERK signal pathway |