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FLASH GENE
Symbol SLC7A2 contributors: mct/npt/pgu - updated : 31-10-2013
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
HGNC id 11060
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 7577 76 697 - 2008 1836947
  • CAT-2A
  • 12 - 7584 72 658 - 2008 1836947
  • CAT-2B
  • 12 - 7580 76 697 - 2008 1836947
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbraindiencephalonhypothalamus highly Homo sapiens
     brainforebraincerebral cortex   Homo sapiens
     brainbasal nucleicaudate nucleus   Homo sapiens
     plexus choroid     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Endocrineislet cell (alpha,beta...)
    Nervousastrocyte Homo sapiens
    Nervousneuron Homo sapiens
    Nervousoligodendrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • HOMOLOGY
    interspecies homolog to murine Slc7a2
    Homologene
    FAMILY
  • amino acid-polyamine-organocation (APC) superfamily
  • cationic amino acid transporter (CAT) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • SLC7A1 mediated L-arginine influx, is essential for both inducible nitric oxide synthase and arginase enzyme activities, which in turn modulate proliferation and differentiation of human epidermal skin cells
  • via arginine transport, plays a critical regulatory role in classical or alternative activation of macrophages
  • by controlling NOS2 and arginase activity, functions as a potent regulator of immunity
  • is a regulator of fibrotic responses in the lung
  • is an important regulator of the immune response during H. pylori infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FRAP1 (FRAP1 activity is associated with the repression of SLC7A2 expression at mRNA and protein level)
  • DDAH1 and L-arginine are substrates of human SLC7A2, SLC22A2, SLC47A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • a single-nucleotide variation in the first intron of the SLC7A2 gene (IVS1-1713 A > G) associated to infantile encephalopathy with severe infantile anorexia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cat2(-/-) mice are significantly more susceptible to the Th1-inducing pathogen Toxoplasma gondii