basic FUNCTION
| mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility |
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TSPAN7 and ATRN are associated with spermatozoa |
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in hippocampal neurons, TSPAN7 regulates AMPA receptor trafficking by limiting PICK1 accessibility to AMPA receptors, suggesting an additional mechanism for the functional maturation of glutamatergic synapses, whose impairment is implicated in intellectual disability |
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plays an important role in cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to SRC, PYK2, and microtubules |
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promoted internalization of DRD2 and its localization to endosomal compartments of the endocytic pathway |
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positive regulator of actin nucleation and stabilization, through the ARP2/3 complex |