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FLASH GENE
Symbol RBMY1A1 contributors: mct - updated : 31-08-2011
HGNC name RNA binding motif protein, Y chromosome, family 1, member A1
HGNC id 9912
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1900 55 496 testis specific 2010 20016065
- - 1793 - 356 testis specific 2010 20016065
lacking an in frame exon in the coding region
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
Text developping germ cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal RNP (RRM) motif
  • four repeats of serine/arginine/glycine/tyrosine (SRGY) box in the C terminal region
  • HOMOLOGY
    interspecies homolog to murine Rbmy1a1
    Homologene
    FAMILY YRBM protein family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in RNA processing or translational control during spermatogenesis
  • germ-cell specific nuclear RNA-binding protein that is involved in spermatogenesis
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding to SFRS10 in splicing into spermatocytes
  • interacting with NEK10 (bind to transcript variant 2 of NEK10 and RBMY1A1 may take part in alternative splicing of NEK10)
  • TRA2B interact directly with the RBMY protein which is implicated in liver cancer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AZFB
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in azoospermia and oligospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS