basic FUNCTION
| actin-dependent regulator of chromatin structure |
|
promoting neurite outgrowth and may be playing a role in the differentiation and maturation of neurons during development, and regulating the engrailed homeotic genes, important regulators of brain development |
|
involved in multiple nuclear functions, including transcriptional regulation, replication, and chromatin assembly |
|
have gene-specific effects on transcription during terminal differentiation |
|
physiological target of PARP1 and poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers |
|
chromatin remodeling gene expressed in diverse tissues, that contributes to the chromatin remodeling complex that facilitates transcription |
|
chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites |
|
evolutionarily conserved nucleosome remodelling factor that regulates gene expression and chromosome organization genome-wide |
|
SMARCA1, SMARCA5 are ATP-dependent chromatin remodelling proteins that assemble, reposition and space nucleosomes, and are robustly expressed in the brain |
|
SMARCA5 and SMARCA1 position nucleosomes adjacent to CTCF and other transcription factors |
|
mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage |
|
|