basic FUNCTION
| transcription factor of kappa light chain gene enhancer in B cells |
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key role for NF-kappaB2 in the regulation of RELA activation and suggest overlap in the function of NF-kappaB members in canonical and noncanonical pathway signaling |
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regulator of development, differentiation apoptosis |
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NFKB1 and NFKB2 proteins serve both as NF-kappaB precursors and inhibitors of NF-kappaB dimers |
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has a role in the early commitment of CD34+ hematopoietic stem and progenitor cells (HSPCs) towards the myeloid lineage |
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functions as the primary inhibitor of the noncanonical NFKB pathway by sequestering NFKB heterodimers in the cytoplasm |
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principal protein involved in the noncanonical NFKB pathway, evolutionarily conserved, and functioning in peripheral lymphoid organ development, B cell development, and antibody production |
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critical role for the combined activity of the RELB and NFKB2 subunits in B cell homeostasis that cannot be compensated for by the canonical NFKB pathway under physiological conditions |