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FLASH GENE
Symbol UBA1 contributors: mct/npt/shn - updated : 21-03-2018
HGNC name ubiquitin-like modifier activating enzyme 1
HGNC id 12469
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 splicing 3616 - 1058 - -
26 splicing 3544 - 1058 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly Homo sapiens
Reproductivefemale systemplacenta  moderately Homo sapiens
Respiratorylung   highly Homo sapiens
cell lineage
cell lines HeLa, BeWo, HepG2, CHO (
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal ubiquitin-fold domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to Uba1, Mus musculus
    ortholog to Uba1, Rattus norvegicus
    ortholog to uba1, Danio rerio
    ortholog to UBA1, Pan troglodytes
    Homologene
    FAMILY
  • ubiquitin-activating E1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • reduced UBA1 localizes mainly in the cytosol, but is translocated from the cytosol to the membrane under conditions of oxidative stress
  • basic FUNCTION
  • ubiquitin-activating enzyme E1, escaping inactivation in human involved in cell cycle progression through S phase
  • catalyzing the first step in ubiquitin conjugation to mark cellular proteins for degradation
  • required for charging the cell-cycle E2s Cdc34A and Cdc34B (
  • major function of UBA1 is to promote degradation of damaged proteins by 26S proteasome by tagging the target proteins with an Ub moiety
  • ubiquitination levels are strongly related to UBA1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with UBE2E2, EBE2D1, UBE2G1, CBL, UBE3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Hsp105alpha (
  • interactions between FUS and proteins involved in neurodegenerative diseases and/or ubiquitin proteasome pathway, such as VCP, SFPQ, UBA1, and 26S proteosome non-ATPase regulatory subunit 12 (PSMD12)
  • USP5 and UBA1, are interacting partners of UBTD2
  • UBA1 and UBD form a stable non-reducible conjugate under overexpression as well as under endogenous conditions after induction of endogenous UBD expression with proinflammatory cytokines
  • does not act as a second E1 activating enzyme for UBD but UBDylation of UBA1 leads to its proteasomal degradation, implying a putative regulatory role of UBD in the ubiquitin conjugation pathway
  • cell & other
    REGULATION
    Phosphorylated by protein kinase Cdc2 (
    Other UBA1 Cys-278 is sensitive to oxidation and can affect UB charging through a change in its proximity to UB
    ASSOCIATED DISORDERS
    corresponding disease(s) SMAX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS