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FLASH GENE
Symbol RPS4X contributors: mct - updated : 11-03-2020
HGNC name ribosomal protein S4, X-linked
HGNC id 10424
RNA
TRANSCRIPTS type messenger
text X-linked isoform
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1474 29 263 - 1994 8139551
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyoblast Homo sapiens
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KOW (Kyprides, Ouzounis, Woese) motif
  • HOMOLOGY
    intraspecies paralog to RPS4Y
    Homologene
    FAMILY
  • ribosomal protein S4e family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 40S ribosomal protein S4 involved in protein biosynthesis, development, cell proliferation, regulation of cell cycle
  • involved in cellular translation and proliferation
  • higher RPS4X expression in both myoblasts and myotubes from women, together with lower methylation levels in the promoter
  • escapes X inactivation
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    associated with a lower risk of death and later disease progression in serous epithelial ovarian cancer
    constitutional     --over  
    RPS4X exhibited the highest expression in XXY (
    tumoral     --low  
    is associated with poor disease-specific and recurrence-free survival in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • RPS4X is an independent prognostic factor in patients with serous epithelial ovarian cancer
  • Therapy target
    ANIMAL & CELL MODELS