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FLASH GENE
Symbol HNRNPH2 contributors: mct - updated : 18-10-2016
HGNC name heterogeneous nuclear ribonucleoprotein H2 (H')
HGNC id 5042
RNA
TRANSCRIPTS type messenger
text these variants encoding the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2392 49 449 - 2011 21068389
2 - 2380 49 449 - 2011 21068389
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen     Homo sapiens
Nervousbrain     Homo sapiens
Reproductivemale systemtestis    Homo sapiens
Respiratorylung     Homo sapiens
Skin/Tegumentskin     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three quasi-RRMs that bind RNA and two glycine-rich domains
  • a nuclear localization sequence (NLS) located within a glycine-rich domain between amino acids 194 and 220 has been identified to interact with the import receptor transportin 1 (TRN1)
  • conjugated RiboP
    HOMOLOGY
    interspecies ortholog to murine Hnrph2
    homolog to Drosophila CG6946
    homolog to C.elegans W02D3.11
    intraspecies homolog to HNRNPF
    Homologene
    FAMILY HNRP family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • shuttle between the nucleus and cytoplasm for pre-mRNA processing and transport
  • basic FUNCTION
  • providing the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm
  • having distinct nucleic acid binding properties that act as a shuttle between the nucleus and the cytoplasm and acting on pre-mRNA to positively or negatively affect spliceosome assembly at nearby splice sites, thereby controlling pre-mRNA splicing
  • the relative levels of HNRNPF and HNRNPH2 in cells, as well as the target sequences in the downstream GRS (guanine-rich sequence) on pre-mRNA, influence gene expression
  • HNRNPH2/HNRNPF regulate genes that are involved in the transition from oligodendrocyte progenitor cells to oligodendrocytes
  • is a splicing regulator of TERF2 pre-mRNA that prevents the expression of TERF2-S, a factor implicated in neuronal differentiation
  • HNRNPH2, and HNRNPF have each been identified in neurons and are important in cellular proliferation, differentiation, and apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of heterogeneous nuclear RNA ribonucleoprotein complex
  • INTERACTION
    DNA
    RNA binding to poly (RG)
    small molecule
    protein
  • developmental changes in HNRNPH2/HNRNPF associated with oligodendrocytes (OLs) differentiation synergistically regulate PLP1 alternative splicing and a G-rich enhancer participates in the regulation
  • HNRNPH2 and HNRNPF regulate PLP1 splicing by recruiting U1snRNP and HNRNPH2 plays a primary role in PLP1 splice site selection
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXSB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS