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FLASH GENE
Symbol CD99 contributors: mct - updated : 05-03-2015
HGNC name CD99 molecule
HGNC id 7082
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 1255 32 185 - 2007 17471235
9 splicing 1207 - 169 - 2007 17471235
10 - 1270 - 160 - 2007 17471235
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinepancreas   highly
Lymphoid/Immunetonsils   highly
Nervousnerve   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
Lymphoid/ImmuneT cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a single long hydrophobic region rich in proline residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to C.elegans co6a8.3
    intraspecies paralog to CD99L2
    Homologene
    FAMILY
  • CD99 family
  • CATEGORY adhesion , antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text type I membrane protein
    basic FUNCTION
  • cell surface glycoprotein whose engagement has been implicated in cell proliferation as well as upregulation and transport of several transmembrane proteins in hematopoietic cells
  • cell surface glycoprotein whose engagement has been implicated in cell proliferation as well as upregulation and transport of several transmembrane proteins in hematopoietic cells
  • involved in T cell adhesion processes
  • involved in crucial processes of cancer malignancy, serving as a curtain raiser for this, so far neglected molecule
  • plays a pivotal role in the reversion of the malignant phenotype
  • acting as a potent suppressor of malignancy in osteosarcoma
  • is essential for leukocyte diapedesis
  • CD99 and CD99L2 act independently of PECAM1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane
  • PECAM1 and CD99 are involved in the reverse transmigration (RT) of tissue-resident dendritic cells (DCs) across lymphatic endothelial cells (LECs) and similar mechanisms promote both diapedesis and RT
  • endothelial CD99 signals through soluble adenylyl cyclase and PRKAA to regulate leukocyte transendothelial migration
  • CD99 and SLC3A2 oppositely regulate ITGB1 signaling
  • CD99-induced dephosphorylation of PTK2 was apparently mediated by the recruitment of PTPN11 to the plasma membrane and subsequent activation of its phosphatase activity
  • important role for CD99 in the pathogenesis of CNS autoimmunity
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    mediated death signaling (novel death pathway)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD99 also binds GOLGA4 9)
  • NFKB2 represses Sp1-mediated transcription at the CD99 promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may have a role in osteosarcoma development and progression
    tumoral     --over  
    contribute to the malignant properties of Ewing's sarcoma cells by promoting growth and migration of tumor cells
    tumoral     --other  
    aberrantly expressed in anaplastic large cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS