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FLASH GENE
Symbol RMRP contributors: mct/pgu - updated : 31-08-2010
HGNC name RNA component of mitochondrial RNA processing endoribonuclease
HGNC id 10031
RNA
TRANSCRIPTS type untranslated transfer
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to Rmrp1
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus,nucleolus
text RNA encoded by a single-copy gene in the nucleus and imported into mitochondria
basic FUNCTION
  • may be involved in the processing of 5,85 RNA ,critical for translation
  • involved in cleavage of RNA in mitochondrial DNA synthesis and nucleolar cleaving of pre-rRNA
  • essential cell growth regulator
  • encodes the untranslated RNA component of the mitochondrial RNA-processing ribonuclease, RNase MRP
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a RNA processing enzyme
  • forming with TERT a ribonucleoprotein complex that has RNA-dependent RNA polymerase activity and produces double-strand RNAs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be interacting with RPS19
  • interacting with TERT
  • PNPT1-dependent import of RMRP into mitochondria
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CHH , SMD2
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS