basic FUNCTION
| catalyzing the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline |
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catalyzes the reduction of delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor (Meng 2006) |
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implicated in oxidation of the anti-tumor drug thioproline (Meng 2006) |
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may be playing a physiologic role in the generation of NADP(+) in some cell types |
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PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline (pMID: 23024808) |
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PYCR1 and PYCR2 could play overlapping, yet non-redundant roles in mitochondrial physiology  |