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FLASH GENE

Symbol

PYCR1

contributors: mct/npt - updated : 31-01-2015

HGNC name	pyrroline-5-carboxylate reductase 1
HGNC id	9721

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006907 7 - 2059 NP_008838 - 319 - 2006 16730026 NM_153824 8 - 1768 NP_722546 - 316 - 2006 16730026 NM_001282279 7 - 1811 NP_001269208 - 288 - 2006 16730026 NM_001282280 8 - 1904 NP_001269209 - 319 - 2006 16730026 NM_001282281 8 - 1897 NP_001269210 - 345 - 2006 16730026

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

A NAD-NADP binding domain

HOMOLOGY

Homologene

FAMILY

pyrroline-5-carboxylate reductase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	localize to mitochondria and primarily act in the conversion of glutamate to proline

basic FUNCTION	catalyzing the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline
	catalyzes the reduction of delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor (Meng 2006)
	implicated in oxidation of the anti-tumor drug thioproline (Meng 2006)
	may be playing a physiologic role in the generation of NADP(+) in some cell types
	PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline (pMID: 23024808)
	PYCR1 and PYCR2 could play overlapping, yet non-redundant roles in mitochondrial physiology

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PARK7 directly bound to PYCR1 (both colocalized in mitochondria, and were suggested to be involved in regulation of mitochondrial membrane potential, but differently)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARCL2B , ARCL3B

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS