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FLASH GENE
Symbol ITGA5 contributors: mct - updated : 20-05-2014
HGNC name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HGNC id 6141
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain
  • a sevenfold repeated structure (7 FG-GAP repeats) with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • The extracellular domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • recognizes the sequence R-G-D in its ligands
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • an alpha chain and a beta chain
  • alpha 5 constituent of VLA-5 receptor
  • complexing with ITGB1 in fibronectin receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by DIDO1, inducing the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS