Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MSMB contributors: mct/npt/pgu - updated : 15-02-2018
HGNC name microseminoprotein, beta-
HGNC id 7372
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 572 12.9 114 - 1991 2054385
variant PSP94
3 - 466 8.7 77 - 1991 2054385
variant PSP57
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemovary    Homo sapiens
 male systemprostate    Homo sapiens
 male systemseminal vesicles   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion seminal fluid
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • beta-microseminoprotein family
  • immunoglobulin superfamily
  • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues
  • playing a role in hormonal control at the pituitary gonadal axis
  • functions as a suppressor of tumor growth and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component seminal plasma protein, forming a tight complex with cysteine-rich secretory protein 3 (CRISP3) from granulocytes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EZH2 (MSMB is silenced by EZH2 in advanced prostate cancer cells)
  • interact with cysteine-rich secretory protein 3 (CRISP3) in seminal plasma
  • both MSMB and an adjacent gene, NCOA4, are subjected to transcriptional control via androgen response elements
  • MSMB bind human CRISP3 (cysteine-rich secretory protein 3) with very high affinity
  • MSMB is a key upstream factor in mediating PRSS8 signaling that regulates PRSS8 expression and action in ovarian cancer cells
  • CRISP2 is a potential binding protein of MSMB
  • CRISP3 binds specifically and with high affinity to MSMB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    suppression of MSMB expression promotes anchorage-independent growth of prostate epithelial cells, but not growth of breast epithelial cells
    tumoral     --low  
    in ovarian cancer with reduced survival
    Susceptibility
  • to prostate cancer, HPC13 (OMIM 611928)
  • to spermatogenic failure associated with male infertility
  • Variant & Polymorphism SNP
  • increasing the risk of prostate cancer
  • rs10993994 is the strongest associated variant to risk of prostate cancer
  • rs10993994 associated with risk of spermatogenic failure
  • Candidate gene
    Marker
  • prostate cancer (PC) biomarker
  • Therapy target
    ANIMAL & CELL MODELS