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FLASH GENE
Symbol IARS contributors: mct - updated : 16-09-2016
HGNC name isoleucine-tRNA synthetase
HGNC id 5330
RNA
TRANSCRIPTS type messenger
text two alternatively spliced variants (5'utr)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
34 - 4716 - 1262 - 1995 7721108
  • IARS Vl
  • 34 - 4546 - 1262 - 1995 7721108
  • IARS-Vs
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinethyroid   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans rha8.6
    Homologene
    FAMILY class 1 aminoacyl tRNA synthetase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a central role in linking amino acids with nucleotide triplets contained in tRNAS
  • IARS enzyme activity seems to be independent of zinc levels and the beneficial effect of zinc supplementation is likely compensating secondary zinc deficiency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GRIDHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS