basic FUNCTION
| negative regulator of Hsp70 chaperone activity |
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steroid hormone regulation |
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multifunctional protein playing key role in the development and progression of cancer and determining response to therapy |
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playing a role in the suppression of the PPP1R15A -mediated cellular stress response and in the survival of cells undergoing stress |
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displaying potent neuroprotective activity against stroke |
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can influence cellular response to stress by multiple mechanisms, potentially influenced by the cell type and nature of the stress signal |
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functioning to inhibit the proteasomal degradation of Tau protein, leading to an accumulation of Tau protein |
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(this role having implications for possible therapeutics of tauopathies that up-regulate the chaperone apparatus of the cell and also for the pathogenesis of the disease) |
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plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments |
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suppress apoptosis and enhance neuronal differentiation |
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acts in a dual role by inhibition of lesion-induced apoptosis and interaction with the inhibitory ROCK signalling cascade |
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inhibits the transactivating functions of TP73 and provide new insight into the mechanisms that control the expression of TP73 |
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involved in different cell processes linked to cell survival |
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able to affect leukemia cell fate by influencing the expression of anti-apoptotic proteins crucial for AML maintenance |
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is a repressor of TGFB1, suggesting a new role for BAG1 in colorectal tumorigenesis |
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suppress apoptosis and enhance neuronal differentiation |
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its expression increased during the cyclic adenosine monophosphate (cAMP)-induced Schwann cell differentiation process |
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co-chaperone BAG1 that plays an important role in targeting structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway |