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FLASH GENE
Symbol CPB1 contributors: mct - updated : 19-03-2008
HGNC name carboxypeptidase B1 (tissue)
HGNC id 2299
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1473 - 417 - Guimaraes (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas   highly Homo sapiens
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion secreted in serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15AA signal/leader peptide
  • a 94-96-amino acid-long propeptide
  • a catalytic moiety with a zinc binding domain
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to C.elegans y59c2a.1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulate the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation
  • cleave off basic C-terminal residues and secreted as inactive zymogens
  • CPB1 hydrolyzes C-terminal lysine and arginine residues generated by tryptic cleavages
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene serum marker for acute pancreatitis
    Marker
    Therapy target
    ANIMAL & CELL MODELS