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FLASH GENE
Symbol GSPT1 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 1
HGNC id 4621
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 7190 - 499 - 1998 9712840
15 - 7166 - 636 - 1998 9712840
15 - 7169 - 637 - 1998 9712840
- - - - - localized not only in the cytoplasm, but also in the nucleus 2014 24569073
  • may also function in the nucleus
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord   highly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
     male systemprostate  highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal unstructured domain (N-domain) and translation elongation factor EEF1A-like GTP-binding domain (C-domain)
  • a leptomycin-sensitive nuclear export signal (NES)
  • a region containing two overlapping PAM2 (PABPC1-interacting motif 2) motifs assumed to bind to the PABC domain of PABPC1
    • HOMOLOGY
    interspecies homolog to yeast cell cycle,G1 to S phase transition 1
    intraspecies homolog to polypeptide chain elongation factor-1 alpha (EF1 alpha)
    Homologene
    FAMILY GTP-binding elongation factor family, ERF3 subfamily
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • is a nucleo-cutoplasmic shuttling protein
    • basic FUNCTION
  • involved in regulation of mammalian cell growth
  • mediating translation termination, and controling the formation of the termination complex by modulating ETF1 protein stability
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • is a GTPase associated with ETF1 in a complex that mediates translation termination in eukaryotes
  • eukaryotic translation termination is mediated by two interacting release factors, ETF1 and GSPT1, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release
  • ETF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase GSPT1 facilitates this peptide release via its interaction with ETF1
  • plays pivotal roles in translation termination and post-termination events including ribosome recycling and mRNA decay
  • could serve as a target in the regulation of gene expression
  • functional interplay between two release factors, ETF1 and GSPT1, involved in eukaryotic translation termination, and GTP hydrolysis by GSTP1 couples codon recognition with peptidyl-tRNA hydrolysis by ETF1
  • is a multifunctional protein that plays pivotal roles in translation termination as well as the initiation of mRNA decay, and also functions in the regulation of apoptosis
  • is a novel regulator of cell death
    • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and stimulating ETF1
  • expression level of GSPT1 controls the formation of the termination complex by modulating ETF1 protein stability
  • proteasomal degradation of GSTP1 controls translation termination complex formation by adjusting the GSPT1 level to that of ETF1
  • important role for ETF1 stimulatory effect on GSPT1 GTPase activity
  • interaction between BIRC5 and GSPT1, GSPT2
  • GSPT1 interact with BIRC5 through the N-terminal domain (NTD: residues 131-200)
  • JMJD4 interacts with the ETF1/GSPT1 translational termination complex in an activity-dependent manner
  • nucleocytoplasmic shuttling protein exported from the nucleus in a manner dependent on CRM1
    • cell & other
    REGULATION
    Other controlled stop-codon directed release
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS