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FLASH GENE
Symbol CALD1 contributors: mct - updated : 21-08-2014
HGNC name caldesmon 1
HGNC id 1441
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5241 93.26 793 predominantly expressed not only in smooth-muscle cells but also in pericryptal fibroblasts in colon 2011 21626272
  • h-CAD, or V1, h-Caldesmon
  • variable in 3'utr length
  • 14 - 4476 62.56 538 non muscle, widely expressed and localized in podosomes/invadopodia 2011 21626272
  • l-CAD1, or V2, l-Caldesmon
  • lacking exon 4
  • lacking the central domain
  • reduction in l-caldesmon facilitates podosome/invadopodia formation and metastasis in colon carcinoma
  • 13 splicing 4291 - 558 cell line 2011 21626272
  • l-CAD2, or V4
  • insertion exon 4
  • 15 - 4551 - 564 - 2011 21626272
    12 - 4213 - 532 - 2011 21626272
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node     Mus musculus
     spleen   highly Mus musculus
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • F-actin cross linking protein
  • acts as a potent repressor of cancer cell invasion
  • one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility
  • playing a role in the regulation of endothelial cytoskeleton and migration
  • actin- and myosin-binding protein found in smooth muscle that inhibits actin activation of myosin ATPase activity
  • actin-linked regulatory protein found in smooth muscle and non-muscle cells
  • important regulator of axon development
  • CALD1, regulated by SOX4 transcriptional activity, contributes to skeletal muscle differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • biological cascade that involved the phosphorylation activation of CALD1 by CDK14 in promoting formation of actin stress fibers
  • SOX4 is a major trans-acting factor for the regulation of CALD1 expression during myoblast differentiation
  • KAT5 chromodomain was found to facilitate SOX4 recruitment to the CALD1 promoter, which is involved in chromatin remodeling at the promoter
  • cell & other
    REGULATION
    Other its function is regulated qualitatively by Ca2+/CALM1 and by its phosphorylation state and quantitatively at the mRNA level, by three different transcriptional regulation of the CALD1 gene
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS