protein
| stimulating cholesterol 27 hydroxylase activity |
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STAR xpression level increased by STS |
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cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STAR/STARD3/STARD5, STARD5, PCTP/STARD10, STARD10 and COL4A3BP, respectively |
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differential cholesterol binding of the two most closely related START domain proteins STAR and STARD3 |
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interacting with UBE2I and FOXL2 (UBE2I-mediated sumoylation at lysine 25 of FOXL2 is required for transcriptional repression of the STAR gene and may be responsible for controlling the development of ovarian follicles) |
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both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping cholesterol-ester hydrolase (CEH)/hormone-sensitive lipase (HSL) inactive and STAR protein expression low |
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AKAP1 interacts with STAR mRNA in a dibutyryl-cAMP-stimulated human steroidogenic adrenocortical carcinoma cell line |
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to prevent mitochondrial impairment, STAR proteolysis is executed by at least 2 mitochondrial proteases, ie, the matrix LONP1 and the inner membrane complexes of the metalloproteases AFG3L2 and SPG7/paraplegin |
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GPLD1 mediates STAR protein and aldosterone synthase (CYP11B2) expression via increasing the phosphorylation (activation) of their regulatory transcription factors |
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mitochondrial PPIF is involved in the inhibitory effect of high-fat diet (HFD) on STAR expression in testes |