basic FUNCTION
| transcriptional activator playing an essential role for hippocampal integrity |
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controlling with CRX the photoreceptor-specific gene transcription |
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controls dendritic patterning during cerebellar development by limiting branch formation and promoting activity-dependent pruning |
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recognizes GC-rich sequences readily identified in the ‘CpG islands’ around the promoters of a variety of genes |
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may be involved in post-transcriptional regulation of GRIN1 expression, such as Y-box proteins which function as both DNA- and RNA-binding proteins |
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regulates dendritic patterning during cerebellar granule neuron development by limiting branching and promoting activity-dependent pruning |
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during cerebellar granule neuron development, SP4-dependent repression of NTF3 is required to limit dendritic branching and thereby promote acquisition of the mature dendritic pattern |
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SP4 molecular pathway could play an important role for a range of psychiatric and neurological diseases (Alzheimer disease) characterized by abnormal NMDA neurotransmission |