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FLASH GENE

Symbol

MCM7

contributors: mct/npt/pgu - updated : 16-01-2018

HGNC name	minichromosome maintenance complex component 7
HGNC id	6950

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005916 15 - 2821 NP_005907 81 719 - 1998 9714754 NM_182776 14 - 2900 NP_877577 - 543 - 1998 9714754 NM_001278595 14 - 3105 NP_001265524 - 543 - 1998 9714754

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune spleen       highly   thymus       highly Nervous brain       highly Reproductive male system testis     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a MCM domain found in DNA-dependent ATPases required for the initiation of eukaryotic DNA replication

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae replication Mcm7 (minichromosome maintenance mutant)
	homolog to murine Mcmd7
	homolog to Drosophila Mcm7
	homolog to C.elegans Mcm7

intraspecies

homolog to cell division cycle 47 (CDC47)

Homologene

FAMILY

MCM family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	in G1 of the two-cell stage, both nuclei had salt-resistant ORC2 and MCM7

basic FUNCTION	participating in the cell cycle control of genome duplication
	acting as a factor allowing the DNA to undergo a single round of replication per cell cycle
	required for DNA replication and cell proliferation
	required for S-phase checkpoint activation upon
	UV-induced damage
	plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in cells
	DNA replication protein that is essential for initiation of DNA replication and maintenance of genomic integrity
	involved in prostate cancer progression, growth and invasion
	independent prognostic factor for human colorectal cancer
	having an essential role for DNA replication
	during S phase, functions as part of the replicative helicase but within the pre-replication complex MCM7 is inactive
	having a role in establishment of bidirectional replication forks
	during S phase MCM7 functions as part of the replicative helicase but within the pre-replication, MCM7 is inactive
	is one of the pivotal DNA replication licensing factors in controlling DNA synthesis and cell entry into S phase
	is an essential component of DNA replication licensing complex
	MCM7 is likely a critical RNA splicing factor
	plays a critical role in the initiation of gene replication
	as a result of MCM7 overexpression, CEP68 was targeted for ubiquitination and proteasomal degradation, thereby rendering centrosome splitting
	LMNB2 interaction with MCM7 promotes non-small cell lung cancer (NSCLC) progression

CELLULAR PROCESS	cell cycle
	nucleotide, replication
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	cell cycle control

PATHWAY

metabolism

signaling

signaling cascade in which EGFR enhances MCM7 phosphorylation and DNA replication through LYN phosphorylation in human cancer cells

a component

CDC45/MCM2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

INTERACTION

DNA

binding

RNA

small molecule	nucleotide,
	ATP

protein	histone H3
	MCM8
	interacts with the ATR-ATRIP complex, and with RAD17
	interacting with CDKN1B
	is a novel RAD17-interacting protein
	interaction with EIF3E (proteasome inhibition strengthens interaction between both proteins and EIF3E stabilizes MCM7)
	interacting with ARHGEF5 and TIPIN, both of which are involved in regulation of DNA replication fork progression
	CCNA2 and MCM7 interact in the chromatin fraction (interaction with Mcm7 is essential for the function of cyclin A in promoting S-phase entry)
	MCM7 interacts with the receptor for activated protein kinase C 1 (RACK1), a protein kinase C (PKC) adaptor
	NCOA4 is a minichromosome maintenance 7 (MCM7)-interacting protein that is able to control DNA replication
	MCM7 binds SF3B3, and the binding motif is located in the N terminus (amino acids 221-248) of MCM7
	directly complexes with CEP68 and VHL
	LMNB2 binds to the C-terminus of MCM7, and competes with the binding of the tumor suppressor retinoblastoma (RB1) protein

cell & other

REGULATION

activated by

MYCN

induced by

growth factor stimulation at the late G1 to S phase

Phosphorylated by

by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in aggressive prostate cancer tumoral     --other   deregulation might be involved in medulloblastoma tumorigenesis

Susceptibility

Variant & Polymorphism

Candidate gene	candidate for molecular targeted cancer therapy in various tumors
Marker	MCM7 polymorphisms may be able to predict the prognosis of acute myeloid leukemia (AML) patients
	good prognostic biomarker for non-small cell lung cancer patients
Therapy target

ANIMAL & CELL MODELS