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FLASH GENE
Symbol HSD17B3 contributors: npt/ - updated : 30-09-2005
HGNC name hydroxysteroid (17-beta) dehydrogenase 3
HGNC id 5212
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1134 34.4 310 - Persson (2009)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Nervousbrain   moderately
Reproductivemale systemtestis  predominantly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Hsd17b3
ortholog to rattus Hsd17b3
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • 17-beta-HSD 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing an essential role in the formation of active intracellular sex steroids
  • catalyzing the conversion of androstenedione to testosterone (last step of testosterone biosynthesis)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text sex determination
    PATHWAY
    metabolism lipid/lipoprotein , hormone
    signaling
    steroid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSD17B3D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS