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FLASH GENE
Symbol DEFA4 contributors: mct - updated : 21-01-2015
HGNC name defensin, alpha 4, corticostatin
HGNC id 2763
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 542 - 97 - 2006 17088326
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
six disulfide-linked cysteines
HOMOLOGY
Homologene
FAMILY alpha-defensin family
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic,vesicle
text from azurophil granules
basic FUNCTION
  • antineutrophil antibacterial peptide, involved in oxygen independent phagocytosis of Gram+, Gram- bacteria, many fungi, some viruses
  • function of the conserved salt bridge in DEFA4 is not linked to bactericidal activity or proteolytic stability of the mature peptide
  • antimicrobial and chemotactic activity of DEFA4 is somewhat comparable to that of other human neutrophil defensins
  • had no intrinsic transcriptional activity, but exhibited adaptor function, because it acted synergistically with serum response factor (SRF) and GATA6 to activate the smooth muscle (SM)-alpha-actin promoter
  • translocate cooperatively across phospholipid bilayers
  • its translocation has implications for its antimicrobial activity as internalized peptide would be available to attack intracellular targets
  • has likely selective bactericidal activities against intestinal microbiota and the activities are dependent on the disulfide bonds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS