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FLASH GENE
Symbol UBE2K contributors: npt - updated : 29-10-2010
HGNC name ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
HGNC id 4914
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 5259 22.4 200 - 2000 10675012
5 splicing 5106 16.6 149 - 2000 10675012
6 - 5130 - 157 - 2000 10675012
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex highly
 brainbasal nucleistriatum highly
 brainhindbraincerebellum lowly
 brainmidbrain  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine residue is required for ubiquitin-thiolester formation
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Ubc1
    homolog to C.elegans F40g9.3
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • implicated in the degradation of Huntingtin and suppression of apoptosis
  • involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death
  • modulates caspase-12 activity via the ubiquitin/proteasome system
  • essential upstream regulator of the expression and activation of caspase-12 in ER stress-mediated Abeta (Amyloid-beta)neurotoxicity
  • mediating the selective degradation of short-lived and abnormal proteins
  • acting as a direct mediator of foam cell formation through polyubiquitination
  • conjugating enzyme that is involved in the cell cycle and suppression of cell death
  • might be involved in the regulation of DIABLO-mediated apoptosis
  • CELLULAR PROCESS cell life, antiapoptosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text second step in ubiquitin conjugation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding selctively to a large region at the N terminus of Huntingtin (HD)
  • interacts directly with huntingtin and may mediate ubiquitination of the neuronal intranuclear inclusions in Huntington disease
  • interacting with DIABLO (promoted degradation of mature DIABLO through the ubiquitin proteasome pathway)
  • cell & other
    REGULATION
    induced by low density lipoprotein (LDL)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS