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FLASH GENE
Symbol C9 contributors: mct - updated : 08-03-2008
HGNC name complement component 9
HGNC id 1358
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2094 - 559 - Kabut (2007)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a perforin domain
  • a LDL receptor domain class A
  • one thrombospondin type I and one EGF-like domain
    • HOMOLOGY
    intraspecies homolog to perforin,highly
    Homologene
    FAMILY complement C6/C7/C8/C9 family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • forming with other components of the membrane attack complex a large and stable transmembrane channel leading to accelerated lysis of target cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • component with C5b, C6, C7, C8 of the late complement complex forming the membrane attack complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein bindingto C8A (role of the N-terminal modules in the C8 alpha subunit)
    cell & other
  • cell surface
    • REGULATION
    activated by cleaved by thrombin
    inhibited by CD59
    ASSOCIATED DISORDERS
    corresponding disease(s) C9
    related resource C9base - Mutation registry for C9 deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS