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FLASH GENE
Symbol KRT13 contributors: mct/npt - updated : 15/09/2008
HGNC name keratin 13
HGNC id 6415
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1719 49.6 458 - Schweizer (2006)
- - 1693 45.5 420 - Schweizer (2006)
early stop codon
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus    
Digestiveintestinelarge intestineanus  
 mouth    
Nervousbrain   highly
Olfactoryolfactory bulb    
Reproductivefemale systemvagina   
 male systemprostate  highly
Respiratorynose    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain
  • four helical domains (1A, 1B, 2A, 2B)
  • interrupted by non alpha helical linkers (L1, 2, 3)
  • the homology domain H1, by variable region (V1, V2) and end sequences (E1, E2), major acidic keratin, type I
  • HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • structural constituent of cytoskeleton involved in the epidermal differentiation
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text epidermal
    PATHWAY
    metabolism
    signaling
    a component
  • associating with KRT4
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WHSN2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS