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FLASH GENE
Symbol PSMB8 contributors: mct/pgu - updated : 03-11-2009
HGNC name proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
HGNC id 9545
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1602 29.8 272 - 2009 19525961
  • LMP7A/LMP7-E1
  • the nonfunctional immunosubunit-variant LMP7E1 expressed by cancer cells
  • incapacity of LMP7E1 to interact efficiently with the proteasome maturation protein (PMID: 16423992)
  • 6 splicing 1135 30.4 276 - 2009 19525961
  • using an alternate in-frame exon in the 5' coding region
  • LMP7B/LMP7-E2
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Psmb8
    homolog to C.elegans pbs-5
    Homologene
    FAMILY
  • PSM, proteasome family
  • proteasome B-type family
  • peptidase T1B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
  • plays critical roles in major histocompatibility complex class I antigen processing
  • playing a unique role in controlling pathogenic immune responses and provide a therapeutic rationale for targeting PSMB8 in autoimmune disorders
  • having a unique role in cytokine production
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
    a component
  • component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    activated by IRF1 (IRF1 mediates upregulation of PSMB8 by IFN-gamma and concerted expression of immunosubunits of the proteasome)
    induced by gamma interferon
    ASSOCIATED DISORDERS
    corresponding disease(s) JCMP
    Susceptibility to psoriasis arthropathica
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target PR-957, a selective immunoproteasome inhibitor, is a therapeutic modality for autoimmune disorders such as rheumatoid arthritis
    ANIMAL & CELL MODELS