Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PSMB8 | contributors: mct/pgu - updated : 03-11-2009 |
HGNC name | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) |
HGNC id | 9545 |
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RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | ortholog to murine Psmb8 |
homolog to C.elegans pbs-5 |
Homologene |
FAMILY | |
| |
|
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm | |
intracellular,nucleus |
basic FUNCTION | |
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CELLULAR PROCESS | protein, degradation |
PHYSIOLOGICAL PROCESS | immunity/defense |
text | anti-pathogen response |
PATHWAY |
metabolism |
signaling |
involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway |
a component |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
protein |
cell & other |
REGULATION |
activated by | IRF1 (IRF1 mediates upregulation of PSMB8 by IFN-gamma and concerted expression of immunosubunits of the proteasome) |
induced by | gamma interferon |
ASSOCIATED DISORDERS |
corresponding disease(s) | JCMP |
Susceptibility | to psoriasis arthropathica |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
| PR-957, a selective immunoproteasome inhibitor, is a therapeutic modality for autoimmune disorders such as rheumatoid arthritis |
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ANIMAL & CELL MODELS |