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FLASH GENE
Symbol PPP2R5D contributors: mct - updated : 23-09-2015
HGNC name protein phosphatase 2, regulatory subunit B (B56), delta isoform
HGNC id 9312
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 splicing 3065 70 602 - 2010 20423611
  • delta-1
  • phosphorylated on serine residues
  • 16 splicing 2969 66.1 570 widely 2010 20423611
  • delta-2
  • potential phosphorylation sites for protein kinases A and C, a bipartite motif of putative nuclear localization signal, a SH3 accessible proline rich domain, and a unique PQ repeat
  • 14 splicing 2747 - 496 - 2010 20423611
    delta-3
    16 - 3082 - 451 - 2010 20423611
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C.elegans C13G3.3A
    intraspecies homolog to PPP2R5B,PPP2R5B,PPP2R5C,PPP2R5E
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text in both cytosol and nucleus in interphase cells, concentrated in the nucleus of mitotic and recently divided cells
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • key upstream regulator of CDC2 activity upon exit from mitosis
  • central checkpoint effector that can control 14-3-3 interactions to promote mitosis
  • nonredundant function for PPP2R5D in phospho-tau homeostasis via an unexpected spatially restricted mechanism preventing CDK5R1 hyperphosphorylation and its subsequent degradation
  • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text muscle contraction
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of protein phosphatase 2 a consisting of a common heterodimeric core enzyme,composed of a 36kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (pr 65 or subunit a) and associating with a variety of regulatory subunits (including three families of subunits b)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of CDC25C during interphase
  • TADA3-interacting partners, are AATF (apoptosis-antagonizing transcription factor), and regulatory subunits of the PP1 and PP2A [PPP1R7 and PPP2R5D]
  • opposes TTK phosphorylation of CASC5 and thereby promotes spindle assembly checkpoint silencing
  • cell & other
    REGULATION
    induced by retinoic acid in neuroblastoma cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD35
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    cause human overgrowth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS