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FLASH GENE
Symbol SRM contributors: mct/npt - updated : 31-08-2009
HGNC name spermidine synthase
HGNC id 11296
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1273 - 302 - Wu (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Nervousbrain   highly
Reproductivefemale systemovary  highly
 male systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain, which contains the active site and is similar in structure to spermine synthase (Wu 2008)
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • spermidine/spermine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • involved in the final step of spermidine biosynthesis
  • transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines (Wu 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    one of four enzymes in the polyamine-biosynthetic pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    may be associated with the mechanism of TGF-beta-induced growth suppression (Nishikawa 1997)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS