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FLASH GENE
Symbol TPD52L1 contributors: mct - updated : 16-02-2008
HGNC name tumor protein D52-like 1
HGNC id 12006
RNA
TRANSCRIPTS type messenger
text alternative transcripts with altered interaction capabilities
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1388 - 204 - Barbaric (2006)
7 - 1409 - 175 - Barbaric (2006)
6 - 1327 - 144 - Barbaric (2006)
7 - 1288 - 131 - Barbaric (2006)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal  
cell lineage
cell lines breast tumor cell lines, erythroleukemia cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other TPD52-like proteins
  • a PEST motif
  • potential glycosylation and phosphorylation sites
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    intraspecies paralog to TPD52,TPD52L2
    Homologene
    FAMILY TPD52 family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in cell proliferation and calcium signaling
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing with TPD52
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis
  • interacting with 14-3-3 proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in childhood leukemia, lymphoid or myeloid
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS