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FLASH GENE
Symbol SERPINB6 contributors: mct/npt - updated : 10-04-2010
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
HGNC id 8950
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1665 - 376 - Scott (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Hearing/Equilibriumearinner  highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
Hearing / Equilibriumcochlea cell
Skin/Tegumentkeratinocyte
cell lineage mast cells
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • high molecular weight
  • HOMOLOGY
    intraspecies homolog to the genes of the serpin cluster on chromosome 18 (SPI@2),highly
    Homologene
    FAMILY
  • serpin family, ovalbumin subgroup
  • Ov-serpin subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • placental thrombin inhibitor
  • cytoplasmic antiprotease
  • playing a role in mast cells, to regulate the activity of endogenous beta-tryptase in the cytoplasm
  • possible role of the SERPINB6 family members in gonad development, gametogenesis, and/or fertilization (Charron 2006)
  • intracellular serpin produced by leukocytes, platelets, endothelial cells, keratinocytes and other epithelial cells that is a potent cathepsin G inhibitor (Scott 2007)
  • protects the intracellular compartment of keratinocytes from ectopic KLK8 (Scott 2007)
  • plays an important role in the inner ear in the protection against leakage of lysosomal content during stress and that loss of this protection results in cell death and sensorineural hearing loss (Sirmaci 2010)
  • potent inhibitor of the monocyte/granulocyte protease cathepsin G, which is stored in azurophilic granules and then released into phagolysosomes or secreted during inflammation (Sirmaci 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing with kallikrein 2 in prostate cancer tissue
  • inhibits th serine protease kallikrein-8 (KLK8) (in human and mouse skin, SERPINB6 and kallikrein-8 co-localize in differentiated keratinocyte) (Scott 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB91
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS