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FLASH GENE
Symbol OXCT1 contributors: mlc - updated : 24-03-2006
HGNC name 3-oxoacid CoA transferase 1
HGNC id 8527
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunethymus   highly
Nervousbrain   moderately
Respiratoryrespiratory tracttrachea  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transit peptide
  • a CoA binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Oxct1
    homolog to chicken OXCT1
    Homologene
    FAMILY 3-oxoacid CoA-transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate
  • rate determining step of ketolysis in extrahepatic tissues, acetoacetate esterification for use in energy production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    succinylcoA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) OXCT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS