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FLASH GENE
Symbol F12 contributors: mct/npt - updated : 15/09/2008
HGNC name coagulation factor XII (Hageman factor)
HGNC id 3530
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2060 - 615 - -
  • a 19 aa signal peptide of 2.1 kda
  • alpha-factor XIIa heavy chain (a 353 aa petide of 39.6 kda, from 20 to 372 aa)
  • beta-factor XIIa light chain (a 9 aa petide of 0.9 kda, from 354 to 362 aa)
  • alpha-factor XIIa light chain (a 243 aa petide of 26.1 kda, from 373 to 615 aa)
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a fibronectin type II domain
  • a fibronectin type I domain
  • two EGF-like domains
  • a cysteine-rich kringle domain,
  • a proline-rich domain
  • a serine protease (peptidase S1) domains
  • conjugated GlycoP
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to rattus F12 (73.5 pc)
    homolog to murine F12 (72.2 pc)
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine protease, participating in the initiation of blood
  • coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaving prekellikrein
  • activating FVII, FXI
  • cell & other
    REGULATION
    activated by cleavage producing a heavy and a light (catalytic) chains
    Other positively regulated by estrogens
    ASSOCIATED DISORDERS
    corresponding disease(s) F12 , HAE3
    Susceptibility to shortening of the activated partial thromboplastin time (aPTT)
    Variant & Polymorphism SNP s2731672 increasing the risk of aPTT (Houlihan 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS