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FLASH GENE
Symbol ADH1A contributors: mct/ - updated : 14-06-2006
HGNC name alcohol dehydrogenase 1A (class I), alpha polypeptide
HGNC id 249
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1456 39.7 375 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestine  highly
 liver   highly
 stomachpylorus  highly
Endocrineadrenal gland   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text infant liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
mono polymer homomer , heteromer , dimer
HOMOLOGY
Homologene
FAMILY
  • zinc-containing alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text detected in the inner cell layers (Vaglenova 2003)
    basic FUNCTION
  • alcohol dehydrogenase (class I), alpha polypeptide, zinc dependent, metabolizing a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products
  • acting as retinol dehydrogenase/retinal reductase, also sites of active retinoid metabolism in the gut, essential for mucosa function and vitamin A absorption (Vaglenova 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SNIP1
  • cell & other
    REGULATION
    Other regulated by GATA2 and HNF-3beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased expression of ADH1A and ADH4 in non-alcoholic steatohepatitis livers (baker 2010)
    Susceptibility to alcohol dependence
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS