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FLASH GENE
Symbol PF4V1 contributors: mct - updated : 20-05-2009
HGNC name platelet factor 4 variant 1
HGNC id 8862
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 741 11.42 104 - 2004 15459074
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid Hydrophobic
STRUCTURE
motifs/domains
  • a 34-amino acid hydrophobic leader sequence
  • a 42-amino acid segment
  • 28-residue carboxy-terminal region corresponding to a domain specifying heparin-binding and cellular chemotaxis
  • HOMOLOGY
    interspecies homolog to C.elegans K03D3.5
    Homologene
    FAMILY
  • platelet factor 4 family
  • intercrine alpha family (small cytokine C-X-C) (chemokine CXC)
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text continuously synthesized and secreted through a constitutive pathway
    basic FUNCTION
  • more potent as PF4 in inhibiting chemotaxis of microvascular endothelial cells toward interleukin-8 (IL-8)/CXCL8 or basic fibroblast growth factor (bFGF)
  • activated platelets release and potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS