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FLASH GENE

Symbol

KRT6B

contributors: npt/mct - updated : 08-06-2018

HGNC name	keratin 6B
HGNC id	6444

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KRT6B 9 - 2331 60 564 - Schweizer (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   mouth tongue     highly   pharynx       highly Respiratory respiratory tract larynx     highly Skin/Tegument skin palm         skin sole         skin appendages nails

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved central rod domain, made of four helical domains (1A,1B,2A,2B) interrupted by non alpha helical linkers (L1,2,3)
	the homology domains H1 and H2, variable region (V1,V2), end sequences (E1,E2)

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to murine Krt2-6b
	ortholog to C.elegans F58E10.3

Homologene

FAMILY	intermediate filament family
	type II keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
text	expressed with family members KRT16 and/or KRT17

basic FUNCTION

required for filament assembly

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

text	cell shape and cell size control
	ectoderm development

PATHWAY

metabolism

signaling

a component	dimerizing with KRT17 and/or KRT16
	heterodimer of a type I (acidic) and a type II (neutral to basic) keratin

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PC212

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS