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FLASH GENE
Symbol GNAO1 contributors: mct - updated : 15-10-2015
HGNC name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
HGNC id 4389
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 3332 - 354 brain 2013 23993195
  • GNAO1 alpha 1
  • 8 splicing 6229 39 354 brain 2013 23993195
  • GNAO1 alpha 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain   predominantly Homo sapiens
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • polypeptide O, GTPase domain with three regions named switches 1, 2 and 3
  • sites for guanine nucleotide binding and effector interaction,followed by
  • an helical domain
  • conjugated LipoP
    HOMOLOGY
    Homologene
    FAMILY G alpha family, subfamily 1
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • modulates potentially the function of ZBTB16 via direct interactions
  • molecular switcher controlling signal transductions and whose deregulation can promote oncogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    GNAO1-GPRIN1 pathway could mediate significant roles in neuronal migration and differentiation at embryonic stages and exert functions in wiring and/or maintenance of specific neural circuitries at postnatal to adult stages
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • ZBTB16 (PLZF) specifically bound to GNAO1
  • interaction between GAP43 and GNAO1 influences the signal transduction pathways leading to differentiation of neural cells
  • GNAO1 interacts with GPRIN1 and outcompetes GPRIN1 from bound SPRY2
  • expression of GNAO1 significantly augmented NDN-mediated cellular responses, such as proliferation and differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EEIV
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for Hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    promising therapeutic target for Hepatocellular carcinoma
    ANIMAL & CELL MODELS
  • mice lacking Gnao show multiple neurological abnormalities, including generalized tremor, occasional seizures, severe motor-control impairment, hyperalgesia, and behavioral abnormalities with early postnatal lethality