basic FUNCTION
| important regulator of both MHC class I and class II transcription |
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stabilizing the binding of RFX-CREB-NF-Y complex |
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transcriptional coactivator involved in inflammatory responses and apoptosis |
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CIITA chromatin in T-cells expressing CIITA display similar histone acetylation and methylation characteristics associated with an open chromatin structure |
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transcriptional co-activator that regulates IFNG1-activated transcription of MHC class I and class II genes |
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TAF1 and CIITA both possess intrinsic acetyltransferase (AT) activity that is required for transcription initiation |
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is a master transcriptional co-activator believed to be exclusively dedicated for antigen presentation |
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plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells, by exerting a selective and intrinsic control of osteoclast differentiation and bone resorption |
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CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice 7) |
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coordinates constitutive and IFNG-induced expression of MHC class II genes |
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is the master regulator of MHC class II gene expression and is a short-lived protein |