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FLASH GENE
Symbol SDC1 contributors: mct - updated : 23-08-2016
HGNC name syndecan 1
HGNC id 10658
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3309 - 310 - 2008 18064305
5 - 3217 - 310 - 2008 18064305
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 liver    
 stomach   highly
Reproductivefemale systemuteruscervix  
 male systemprostate   
Respiratoryrespiratory tractlarynx   
Urinarybladder   highly
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
cell lineage distinct stages of differentiation of normal lymphoid cells (pre-B)
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytoplasmic domain binding to RAB5A, a small GTPase that regulates intracellular trafficking and signaling events, and this interaction controls the onset of SDC1 shedding (Hayashida 2008)
  • a transmembrane domain having a regulatory function in controlling focal adhesion disassembly, which in turn controls cell migration speed
  • HOMOLOGY
    Homologene
    FAMILY syndecan proteoglycan family
    CATEGORY structural protein , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    text
  • translocates into the nucleus and hampers tumor cell proliferation
  • basic FUNCTION
  • cell surface proteoglycan bearing both heparan sulfate and chondroitin sulfate and linking the cytoskeleton
  • to the interstitial matrix
  • involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling
  • playing an essential role in maintaining intestinal epithelial barrier function
  • physiological binding partner of TIAM1 and the PDZ domain has a function in cell-matrix adhesion and cell migration
  • regulates mesenchymal tumor cell adhesion and migration, and its different domains have differential effects
  • is a regulator of focal adhesion disassembly in migrating lung epithelial cells
  • cell surface proteoglycan that can organize co-receptors into a multimeric complex to transduce intracellular signals
  • in the germinal niche is a key regulator of the maintenance and proliferation of neural progenitor cells (NPCs) during cortical neurogenesis
  • promotes vascular smooth muscle cells (vSMCs) differentiation and quiescence
  • modulates the motility and resolution responses of macrophages
  • role of the syndecan (SDC1) heparan sulphate proteoglycans, the small intracellular adaptor SDCBP and associated regulators in the biogenesis and loading of exosomes with cargo
  • may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production
  • soluble (shed) form of SDC1 has paracrine and autocrine functions and is normally produced in a regulated fashion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT
  • SDC1 and CASPR4, are potential TIAM1 PDZ domain binding proteins
  • SDC1 restrains migration in lung epithelium by activating RAP1A to slow focal adhesion disassembly
  • tyrosine phosphorylation of SDC1 triggers the robust recruitment of cortactin, which we found to be an essential mediator of efficient actin-dependent endocytosis
  • alternative binding of IL34 to chondroitin sulphates and SDC1 at the cell surface that modulates CSF1R activation
  • HPSE stimulates the exosomal secretion of SDCBP, SDC1 and certain other exosomal cargo, such as CD63, in a concentration-dependent manner
  • on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in an estrogen receptor-negative, highly proliferative breast carcinoma subtype
    constitutional     --low  
    before the clinical onset of preeclampsia, with reduced expression of SDC1 in the delivered placenta, suggesting a role for glycocalyx disturbance in preeclampsia pathophysiology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • soluble SDC1 may be applicable as a surrogate marker of SLE disease activity
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    SDC1/TNFSF13 signaling may be a potential therapeutic target for patients with active SLE
    ANIMAL & CELL MODELS
  • Sdc1 -/- mice (Alexander (00))
  • Sdc1(-/-) mice are able to synthesize and maintain a hydrodynamically relevant glycocalyx, which indicates that syndecan-1 is not an essential anchoring protein for the glycocalyx