protein
| WDR74 is a factor that specifically dissociates from the complex depending on the ATPase activity of NVL |
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WDR74 associates with the D1 AAA domain of NVL, which represents a novel mode of binding of a substrate with a type II AAA-ATPase |
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WDR74 associates with MTREX, the nuclear exosome-assisting RNA helicase, whose dissociation is prohibited by an ATPase-deficient mutant of the AAA-type chaperone NVL |
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dissociation of WDR74 from MTREX in a late stage of rRNA synthesis is thought to be required for appropriate maturation of the pre-60S particles |
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critical role of WDR74 in regulating TGFB1 signaling |
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WDR74 is a MTREX-interacting partner, whose dissociation is stimulated by the ATP hydrolysis of NVL |