Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WDR66 contributors: mct - updated : 17-10-2018
HGNC name WD repeat domain 66
HGNC id 28506
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3785 - 1149 highly and predominantly expressed in the testis and moderately expressed in other ciliated tissues 2001 11814058
18 - 3470 - 941 negligible expression in all tested tissues 2001 11814058
  • C-terminally truncated isoform
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine WD40-repeat domains circularly arranged around the central-pair complex of microtubules (9 + 2 structure)
  • one calcium-binding EF-hand domain is present in the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localizes along the spermatozoon flagellum
  • basic FUNCTION
  • play an important role in esophageal squamous cell carcinoma growth and invasion as a positive modulator of epithelial-mesenchymal transition
  • plays a structural role during biogenesis of the spermatozoon flagellum in vertebrates
  • might be required for the extension of the mitochondrial sheath (MS) along the midpiece of the spermatozoon flagellum
  • is associated with sperm flagellar development and human male infertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MIMAF5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    cause sperm flagellar defects and human male infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    might be a novel drug target for the treatment of esophageal squamous carcinoma
    ANIMAL & CELL MODELS