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FLASH GENE
Symbol NUDT18 contributors: mct - updated : 26-06-2017
HGNC name nudix hydrolase 18
HGNC id 26194
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1519 - 323 - 2012 22556419
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • is specifically active against 8-oxo-dGDP and hardly cleaves 8-oxo-dGTP
  • can degrade 8-oxo-GDP as efficiently as 8-oxo-dGDP, which is in contrast to the finding that NUDT1 and NUDT15 show a limited activity against the ribonucleotide counterpart, 8-oxo-GTP
  • NUDT1, NUDT15, NUDT18 may function together to help maintain the high fidelity of DNA replication and transcription under oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS