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FLASH GENE
Symbol MRFAP1 contributors: mct - updated : 31-01-2017
HGNC name Morf4 family associated protein 1
HGNC id 24549
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2184 - 127 - 2012 22038470
3 - 2112 - 103 - 2012 22038470
3 - 2065 14 127 - 2012 22038470
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus of MRFAP1 are critical for the interaction with TRAPPC2
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • involves in maintaining normal histone modification levels by negatively regulating recruitment of the NuA4 (nucleosome acetyltransferase of H4) histone acetyltransferase complex to chromatin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAPPC2 is physically associated with protein associated with MRG 14 kDa (MRFAP1), a nuclear protein that interacts with the transcription factor MORF4L1
  • nucleus-localized TRAPPC2 may play a role in regulation of transcriptional activities of the MRG family of transcription factors via binding to MRFAP1
  • MRFAP1 may regulate the ability of MORF4L1 to interact with chromatin-modifying enzymes by binding to MORF4L1 in a mutually exclusive manner with MRGBP
  • MRFAP1 bound to a number of E3 ubiquitin ligases, including CUL4B, but not to components of the NuA4 complex, including MRGBP, which bound to MORF4L1 (
  • MRFAPinteractor of the F-box protein FBXW8, and is degraded by means of the ubiquitin ligase CUL7/FBXW8 during mitotic anaphase-telophase transition and accumulated in mitotic metaphase
  • CUL7/FBXW8-mediated destruction of MRFAP1 is a regulatory component monitoring the anaphase-telophase transition and preventing genomic instability
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS