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FLASH GENE
Symbol TMTC1 contributors: mct - updated : 06-12-2016
HGNC name transmembrane and tetratricopeptide repeat containing 1
HGNC id 24099
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 8841 - 774 - 2014 24764305
18 - 8750 - 882 - 2014 24764305
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ER targeting signal sequences and multiple hydrophobic segments, suggestive of polytopic membrane proteins that are targeted to the secretory pathway
  • HOMOLOGY
    Homologene
    FAMILY TMTC family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • TMTC1 and TMTC2 are ER membrane proteins that interact with the ER calcium uptake pump SERCA2B (both) and calnexin (TMTC2 only)
  • basic FUNCTION
  • TMTC1 and TMTC2 are ER proteins involved in ER calcium homeostasis
  • likely TMTC1, TMTC2, TMTC3 actively participate in ER function and homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS