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FLASH GENE
Symbol TMIGD2 contributors: mct - updated : 27-01-2016
HGNC name transmembrane and immunoglobulin domain containing 2
HGNC id 28324
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1270 - 278 - 2012 22419821
5 - 1282 - 282 - 2012 22419821
- - 918 - 162 - 2012 22419821
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline-rich cytoplasmic domain, associated with multiple Src homology 3 (SH3)-containing signaling proteins
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction
  • its activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration
  • likely is a novel receptor that plays an important role in cell-cell interaction, cell migration, and angiogenesis
  • has unique functions in the regulation of the human immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C10orf54 is a specific ligand for TMIGD2
  • TMIGD2was identified as one of the receptors for HHLA2
  • TMIGD2 is one of HHLA2 receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS