basic FUNCTION
| TMEM38A, TMEM38B channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores |
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TMEM38B channels take an active part in Ca(2+) signalling to establish specialised functions in type II cells and are thus essential for perinatal lung maturation |
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leads to compromised K(+) permeation and Ca(2+) release across the SR/ER membrane |
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may also function as accessory proteins that directly modulate the ryanodine receptor/IP3 receptor channel functions |