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FLASH GENE
Symbol TMEM38B contributors: mct - updated : 10-11-2015
HGNC name transmembrane protein 38B
HGNC id 25535
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3558 - 291 - 2013 23316006
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
text
  • expressed in the endoplasmic reticulum (ER) of all tissues
  • basic FUNCTION
  • TMEM38A, TMEM38B channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores
  • TMEM38B channels take an active part in Ca(2+) signalling to establish specialised functions in type II cells and are thus essential for perinatal lung maturation
  • leads to compromised K(+) permeation and Ca(2+) release across the SR/ER membrane
  • may also function as accessory proteins that directly modulate the ryanodine receptor/IP3 receptor channel functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OIXIV
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tric-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth