Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SETD6 contributors: mct - updated : 17-06-2014
HGNC name SET domain containing 6
HGNC id 26116
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2985 - 473 - -
8 - 2913 - 449 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • is a transcriptional repressor, in agreement with its association with HDAC1 and MTA2
  • is an essential factor for nuclear receptor signaling and cellular proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • lysine methylation of the NFKB1 subunit RELA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NFKB1 signaling
  • monomethylates the RELA subunit of nuclear factor kappa B (NFKB1)
  • H2AFZ is monomethylated at lysine 7 (H2AZK7me1) by the lysine methyltransferase SETD6
  • association with HDAC1 and MTA2
  • modifies the histone variant H2AZ, a key component of nuclear receptor-dependent transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS